LotaV3, France, Analysis, bibRecord, 000143

Hormonal influences on the middle-affinity estrogen-binding sites in the liver of the newt Pleurodeles waltl

Identifieur interne : 000143 ( France/Analysis ); précédent : 000142; suivant : 000144

Hormonal influences on the middle-affinity estrogen-binding sites in the liver of the newt Pleurodeles waltl

Auteurs : H. Dupont [France] ; C. Cayrol [France] ; P. Deparis [France]

Source :

General and Comparative Endocrinology [ 0016-6480 ] ; 1988.

RBID : ISTEX:E23DE50693DC90DFC03484C999C67DC838FAA615

Abstract

The effects of hormonal changes on the male-specific, middle-affinity, estrogen-binding component (MEBC) were investigated in the Pleurodele. Induction of MEBC was shown to be under androgen control, similar to that observed for the cytoplasmic middle-affinity estrogen-binding sites in rat liver and human hepatoma cells. But, in contrast to the malespecific middle-affinity estrogen-binding sites identified in the rat, the administration of estrogen to male Pleurodeles did not lead to the disappearance of MEBC but raised levels significantly. The MEBC displays the properties of type II middle-affinity estrogen-binding sites, which are characterized by an oestrogen-dependent rise, a sensitivity to reducing agents, a specificity for diethylstilbestrol, and a binding capacity enhanced by increasing dilutions of cytosol. In female Pleurodeles, MEBC can be induced by treatment with androgens. This induction appears to be modulated by the estrogen/androgen ratio. The induction of MEBC and the estrogen-dependent increase in the male were not found to be correlated with hepatocyte proliferation.

Url:

https://api.istex.fr/document/E23DE50693DC90DFC03484C999C67DC838FAA615/fulltext/pdf

DOI: 10.1016/0016-6480(89)90094-4

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001669
to stream Istex, to step Curation: 001669
to stream Istex, to step Checkpoint: 001307
to stream Main, to step Merge: 001899
to stream Main, to step Curation: 001796
to stream Main, to step Exploration: 001796
to stream France, to step Extraction: 000143

Links to Exploration step

ISTEX:E23DE50693DC90DFC03484C999C67DC838FAA615

Le document en format XML

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<author><name sortKey="Deparis, P" sort="Deparis, P" uniqKey="Deparis P" first="P." last="Deparis">P. Deparis</name>
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<front><div type="abstract" xml:lang="en">The effects of hormonal changes on the male-specific, middle-affinity, estrogen-binding component (MEBC) were investigated in the Pleurodele. Induction of MEBC was shown to be under androgen control, similar to that observed for the cytoplasmic middle-affinity estrogen-binding sites in rat liver and human hepatoma cells. But, in contrast to the malespecific middle-affinity estrogen-binding sites identified in the rat, the administration of estrogen to male Pleurodeles did not lead to the disappearance of MEBC but raised levels significantly. The MEBC displays the properties of type II middle-affinity estrogen-binding sites, which are characterized by an oestrogen-dependent rise, a sensitivity to reducing agents, a specificity for diethylstilbestrol, and a binding capacity enhanced by increasing dilutions of cytosol. In female Pleurodeles, MEBC can be induced by treatment with androgens. This induction appears to be modulated by the estrogen/androgen ratio. The induction of MEBC and the estrogen-dependent increase in the male were not found to be correlated with hepatocyte proliferation.</div>
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   |texte=   Hormonal influences on the middle-affinity estrogen-binding sites in the liver of the newt Pleurodeles waltl
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Hormonal influences on the middle-affinity estrogen-binding sites in the liver of the newt Pleurodeles waltl

Hormonal influences on the middle-affinity estrogen-binding sites in the liver of the newt Pleurodeles waltl

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri